[Thrombolytic recombinant tissue plasminogen activator (rt-PA) treatment in the acute ischemic stroke with limb...

We report three female patients, aged 77, 89, and 92 years, with arterial emboli in their limbs that developed before and after recombinant tissue plasminogen activator (rt-PA) treatment for cerebral infarction. Arterial embolism in one limb developed in two patients before rt-PA treatment and in one during rt-PA treatment at the time of the first medical examination. Thrombectomy was performed in two patients. In all patients, the arterial emboli of the extremities were accompanied by acute cardiogenic cerebral emboli. Patients with cardiogenic cerebral emboli can also develop emboli in the extremities. Particularly, during rt-PA treatment of cerebral infarction, the presence of other possible thromboembolisms, in addition to hemorrhagic complications and changes in neurological symptoms, should be examined.