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The Role of Secretory Pathways in Candida albicans Pathogenesis

Christiane Rollenhagen1,2, Sahil Mamtani1, Dakota Ma1,3

  • 1Medicine Service, White River Junction VA Medical Center, White River Junction, VT 05009, USA.

Journal of Fungi (Basel, Switzerland)
|February 28, 2020
PubMed

Insights

This review explores how the secretory pathway aids Candida albicans in becoming an invasive pathogen. Understanding these mechanisms is key to combating fungal infections.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Mycology

Background:

  • Candida albicans is a common human commensal fungus.
  • It can transition to an opportunistic pathogen, causing infections.
  • Virulence factors include secreted proteins, hyphae, and biofilms.

Purpose of the Study:

  • To review the role of secretory pathways in Candida virulence.
  • To focus on the model organism Candida albicans.
  • To highlight the importance of membrane trafficking in fungal pathogenesis.

Main Methods:

  • Literature review of studies on Candida albicans virulence.
  • Analysis of research on secretory pathways and membrane trafficking.
  • Synthesis of findings related to fungal pathogenesis.

Main Results:

  • Secretory pathways are crucial for virulence factor secretion.
  • Hyphal and biofilm formation depend on the secretory system.
  • Membrane trafficking underpins key pathogenic processes.

Conclusions:

  • The secretory pathway is a critical determinant of Candida albicans virulence.
  • Targeting secretory mechanisms offers potential therapeutic strategies.
  • Further research into fungal secretion is warranted for infection control.
Keywords:
Candida albicansbiofilmfilamentationpathogenesissecretiontraffickingvirulence

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