Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

5.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

15.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
15.7K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.8K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.8K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

5.2K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.2K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

7.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.5K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HDAC7 is a key factor for the germinal center reaction and its underexpression is associated with DLBCL prognosis.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

HDAC7 induction combined with standard-of-care chemotherapy provides a therapeutic advantage in t(4;11) infant B-cell acute lymphoblastic leukemia.

Biomarker research·2025
Same author

The HDAC7-TET2 epigenetic axis is essential during early B lymphocyte development.

Nucleic acids research·2022
Same author

Insights into the mechanisms underlying aberrant SOX11 oncogene expression in mantle cell lymphoma.

Leukemia·2021
Same author

Epigenetic Control of Infant B Cell Precursor Acute Lymphoblastic Leukemia.

International journal of molecular sciences·2021
Same author

HDAC7 is a major contributor in the pathogenesis of infant t(4;11) proB acute lymphoblastic leukemia.

Leukemia·2020

Related Experiment Video

Updated: Dec 27, 2025

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

12.9K

MYC's Fine Line Between B Cell Development and Malignancy.

Oriol de Barrios1, Ainara Meler1, Maribel Parra1

  • 1Lymphocyte Development and Disease Group, Josep Carreras Leukaemia Research Institute, IJC Building, Campus ICO-Germans Trias i Pujol, Ctra de Can Ruti, 08916 Barcelona, Spain.

Cells
|February 28, 2020
PubMed
Summary
This summary is machine-generated.

The MYC gene is crucial for B cell development but its dysregulation drives leukemia and lymphoma. Understanding MYC

Keywords:
B cell developmentMYCleukemialymphoma

More Related Videos

Flow Cytometric Characterization of Murine B Cell Development
08:25

Flow Cytometric Characterization of Murine B Cell Development

Published on: January 22, 2021

18.1K
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

7.9K

Related Experiment Videos

Last Updated: Dec 27, 2025

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

12.9K
Flow Cytometric Characterization of Murine B Cell Development
08:25

Flow Cytometric Characterization of Murine B Cell Development

Published on: January 22, 2021

18.1K
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

7.9K

Area of Science:

  • Immunology
  • Molecular Biology
  • Oncology

Background:

  • The transcription factor MYC plays a critical role in B lymphocyte development.
  • Proper MYC expression modulation is vital for B cell differentiation stages.
  • MYC is a proto-oncogene implicated in various hematological malignancies.

Purpose of the Study:

  • To review the role of MYC in B cell development.
  • To explore the oncogenic functions of MYC in hematological cancers.
  • To highlight the significance of MYC regulatory circuits.

Main Methods:

  • Literature review of MYC's function in B cell biology.
  • Analysis of MYC's role in oncogenesis.
  • Examination of MYC overexpression mechanisms in leukemia and lymphoma.

Main Results:

  • MYC is transiently expressed during B cell development, with basal levels maintained until terminal differentiation.
  • Aberrant MYC expression in leukemia and lymphoma leads to uncontrolled proliferation and blocked differentiation.
  • Overexpression of MYC in these cancers is primarily due to gene amplification, translocations, and transcriptional dysregulation.

Conclusions:

  • MYC's precise regulation is essential for normal B cell development.
  • Dysregulated MYC is a key driver of B cell malignancies.
  • Understanding MYC's regulatory circuitry is crucial for therapeutic strategies in leukemia and lymphoma.