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Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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TNFα Blockade in Checkpoint Inhibition: The Good, the Bad, or the Ugly?

Jeffrey S Weber1, Michael A Postow2

  • 1Laura and Isaac Perlmutter Comprehensive Cancer Center at NYU Langone Health, New York, New York. Jeffrey.Weber@nyulangone.org.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|February 28, 2020
PubMed

The impact on survival of steroids and TNFα blockade to treat immune-related toxicity from checkpoint blockade with ipilimumab, nivolumab/pembrolizumab, or combined ipilimumab and nivolumab was assessed using data from a large national database. Using steroids was associated with better survival than the use of TNFα-blocking antibodies such as infliximab.See related article by Verheijden et al., p. 2268.

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