Related Experiment Video
Updated: Dec 27, 2025

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
Published on: May 16, 2025
Physician Prescribing Patterns and Risk of Future Long-Term Opioid Use Among Patients With Rheumatoid Arthritis: A
Yvonne C Lee1, Bing Lu2, Hongshu Guan2
1Northwestern University Feinberg School of Medicine, Chicago, Illinois, and Brigham and Women's Hospital, Boston, Massachusetts.
Opioid prescribing rates for rheumatoid arthritis (RA) patients vary significantly. Higher baseline opioid prescribing by physicians strongly predicts future long-term opioid use in RA patients, even after accounting for patient factors.
Area of Science:
- Rheumatology
- Pain Management
- Health Services Research
Background:
- Rheumatoid arthritis (RA) management often involves pain control, with opioids sometimes used.
- Understanding variations in opioid prescribing patterns is crucial for patient safety and effective pain management.
- Long-term opioid use poses significant risks, including addiction and overdose.
Purpose of the Study:
- To assess the variability of opioid prescribing rates among physicians treating patients with rheumatoid arthritis (RA) in the US.
- To determine if initial opioid prescribing rates predict the likelihood of patients developing long-term opioid use.
Main Methods:
- Patients with RA were identified from the Corrona RA Registry.
- Baseline opioid prescribing rates were calculated per physician.
- Generalized linear mixed models were used to estimate odds ratios for long-term opioid use.
Main Results:
- Opioid prescription rates varied widely among physicians.
- Patients treated by physicians with moderate (OR 1.89) and high (OR 2.01) baseline opioid prescribing rates had significantly higher odds of long-term opioid use compared to those with very low rates.
- No significant difference in long-term opioid use was observed for patients of low-intensity prescribers (OR 1.16).
Conclusions:
- Baseline opioid prescribing patterns are a significant predictor of future long-term opioid use in RA patients.
- Physician prescribing habits play a critical role in the trajectory of opioid use for RA patients.
- Interventions targeting physician prescribing behavior may help mitigate long-term opioid use in this population.
Related Concept Videos
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Analgesia and Pain Management
Opioid Analgesics: Morphine and Other Natural Cogeners
Rheumatic Heart Disease III: Medical Management
Prescription, Nonprescription and Orphan Drugs
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Therapeutic Drug Monitoring: Affecting Factors

