Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

3.5K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
3.5K
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

5.3K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
5.3K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.2K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

491
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
491
Transmission-based Precautions I: Contact, Enteric, and Droplets01:17

Transmission-based Precautions I: Contact, Enteric, and Droplets

4.4K
Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
4.4K
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

373
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
373

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Guiding Principles of Integrated Cancer Care Delivery Within a Regional Health System.

The Journal of surgical research·2026
Same author

Navigating the complexities of rectal cancer management: Shared decision-making and patient perspectives in critical choices.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2026
Same author

Beyond Bleeding, Infection, Damage to Surrounding Structures: Challenges and Opportunities When Communicating about Surgical Risks.

Clinics in colon and rectal surgery·2025
Same author

Bundled Payment Programs and Changes in Practice Patterns and Episode Spending in Major Gastrointestinal Surgery.

Health services research·2025
Same author

Neoadjuvant Chemoradiation Does Not Improve Outcomes for Patients Undergoing Resection for Upper Rectal Cancer: A US Rectal Cancer Consortium Analysis.

The American surgeon·2025
Same author

Small Bowel Stricture in a Crohn's Patient: An Unrelated Etiology.

Case reports in gastrointestinal medicine·2025

Related Experiment Video

Updated: Dec 27, 2025

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

9.3K

Clostridium difficile Infection: An Epidemiology Update.

Ana C De Roo1,2, Scott E Regenbogen1,2

  • 1Center for Healthcare Outcomes and Policy, University of Michigan, Ann Arbor, Michigan.

Clinics in Colon and Rectal Surgery
|February 28, 2020
PubMed
Summary

Clostridioides difficile infection (CDI) poses significant risks, especially for older adults and those with underlying conditions. Understanding specific bacterial strains and medication impacts is crucial for effective treatment and reducing recurrence.

Keywords:
Clostridium difficilehealthcare associated infectionproton pump inhibitorribotypestatins

More Related Videos

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

13.1K
A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
09:12

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection

Published on: June 15, 2018

10.4K

Related Experiment Videos

Last Updated: Dec 27, 2025

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

9.3K
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

13.1K
A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
09:12

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection

Published on: June 15, 2018

10.4K

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Epidemiology

Background:

  • Clostridioides difficile infection (CDI) is a major healthcare-associated infection causing significant morbidity and mortality.
  • Risk factors include antibiotic use, severe illness, and increasing community-associated cases.
  • Patients face risks of recurrence or reinfection even after initial recovery.

Purpose of the Study:

  • To review the epidemiology and risk factors of Clostridioides difficile infection.
  • To highlight the impact of specific C. difficile ribotypes on infection severity.
  • To discuss potential medication-related risk and protective factors.

Main Methods:

  • Review of existing pharmaco-epidemiologic and clinical studies.
  • Analysis of data on C. difficile ribotypes and their associated characteristics.
  • Synthesis of information on risk factors and treatment implications.

Main Results:

  • Certain C. difficile ribotypes (e.g., BI/NAP1/027) are linked to increased antibiotic resistance, morbidity, and mortality.
  • Proton pump inhibitors have been suggested as a risk factor, while statins may offer protection, though findings are inconsistent.
  • Community-associated CDI is an emerging concern in previously healthy individuals.

Conclusions:

  • CDI remains a high-morbidity infection requiring targeted treatment strategies.
  • Further understanding of ribotypes and medication interactions is essential for managing high-risk patients.
  • Improved knowledge can aid in preventing recurrence and reducing overall mortality.