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Published on: February 3, 2023
Enhanced dissolution of poorly soluble antiviral drugs from nanoparticles of cellulose acetate based solid dispersion
Sonal Mazumder1, Ashish Kumar Dewangan1, Naresh Pavurala2
1Department of Chemical Engineering, Birla Institute of Science and Technology, Pilani, Rajasthan 333031, India.
Abstract:
Polysaccharide-based polymers were used to produce nanoparticles of poorly soluble antiviral drugs using a rapid precipitation process. The structure-property relationships of four novel cellulose acetate-based polymers were studied for their solubility enhancement of poorly soluble drugs. Particles were purified by dialysis, and dried powders were recovered after freeze-drying. The particle diameters were 150-200 nm. The target drug loading in the particles was 25 wt%, and the drug loading efficiencies were 80-96%. The effects of the formulation process and nanoparticle properties on drug solubility were investigated. All nanoparticles afforded increased solubility and faster release compared to pure drugs. Drug release was a function of the relative hydrophobicity (or solubility parameters) of the polymers.
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