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Polymer Classification: Crystallinity01:21

Polymer Classification: Crystallinity

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Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Polymers02:34

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The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
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Step growth polymerization involves bi or multifunctional monomers. Bifunctional monomers react to form linear step growth polymers, whereas multifunctional monomers react to form non-linear or branched polymers.
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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst
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Cellulose based polymers in development of amorphous solid dispersions.

Rahul B Chavan1, Sneha Rathi1, Vaskuri G S Sainaga Jyothi1

  • 1Solid State Pharmaceutical Research Group (SSPRG), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad 500037, India.

Asian Journal of Pharmaceutical Sciences
|February 28, 2020
PubMed
Summary
This summary is machine-generated.

Cellulose derivatives are crucial stabilizers for amorphous solid dispersions, preventing drug crystallization and enhancing drug delivery. New derivatives offer expanded applications in pharmaceutical formulations.

Keywords:
Amorphous formCrystallizationHPMCPolymersSupersaturation

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Area of Science:

  • Pharmaceutical Science
  • Polymer Chemistry

Background:

  • Cellulose derivatives are widely used as stabilizers in amorphous solid dispersions.
  • Over 20 marketed products utilize cellulose derivatives, underscoring their significance.
  • These polymers enhance drug solubility, inhibit crystallization, and improve drug release.

Purpose of the Study:

  • To review mechanisms of drug crystallization inhibition by cellulose derivatives.
  • To summarize existing and novel cellulose derivatives for amorphous formulations.
  • To provide a SWOT analysis and discuss critical quality attributes for development.

Main Methods:

  • Literature review of cellulose derivatives in amorphous solid dispersions.
  • Analysis of crystallization inhibition mechanisms.
  • SWOT analysis and CQA assessment for formulation development.

Main Results:

  • Cellulose derivatives offer diverse physicochemical properties beneficial for amorphous solid dispersions.
  • Exploiting their chemistry and pH responsiveness has led to new derivative synthesis.
  • SWOT analysis and CQA identification highlight development challenges and opportunities.

Conclusions:

  • Cellulose derivatives are vital for amorphous solid dispersion technology.
  • Understanding their mechanisms and properties guides future formulation development.
  • Further research into new derivatives and CQAs will advance the field.