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Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease
Published on: February 9, 2016
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Modulating intestinal mucus barrier for nanoparticles penetration by surfactants
Xin Zhang1, Wei Dong1, Hongbo Cheng1
1School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Asian Journal of Pharmaceutical Sciences
|February 28, 2020
Summary
Surfactants can improve nanoparticle drug delivery by altering the intestinal mucus barrier. Tween 80 shows promise for enhancing nanoparticle penetration with minimal impact on mucus properties, suggesting improved peroral drug delivery.
Area of Science:
- Biomaterials Science
- Drug Delivery
- Nanotechnology
Background:
- Intestinal mucus barrier impedes drug delivery, particularly for nanoparticles.
- Developing effective peroral delivery systems remains a challenge for both small and large molecules.
Purpose of the Study:
- To investigate how anionic and nonionic surfactants affect nanoparticle penetration through the intestinal mucus barrier.
- To evaluate the ability of surfactants to modulate mucus properties for enhanced drug delivery.
Main Methods:
- Utilized fluorescently labeled poly (lactic-co-glycolic acid) (PLGA) nanoparticles.
- Employed multiple particle tracking (MPT) to analyze nanoparticle movement in mucus.
- Assessed mucus rheology and morphology changes induced by surfactants.
- Conducted rat intestinal villus penetration studies.
Main Results:
- Surfactant pretreatment increased nanoparticle effective diffusivity in mucus by 2-3 times.
- Sodium dodecyl sulfate (SDS) increased mucus viscosity and viscoelasticity; poloxamer decreased these properties.
- Tween 80 maintained native mucus rheological and morphological characteristics.
- Surfactant-mediated mucus modulation significantly enhanced nanoparticle penetration in intestinal villi.
Conclusions:
- Altering the mucus microenvironment with surfactants can enhance nanoparticle penetration.
- Tween 80 is a promising candidate for facilitating nanoparticle transport across the mucus barrier due to its ability to preserve mucus properties and its favorable safety profile.
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