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Computer-aided baker's yeast fermentations.

H Y Wang, C L Cooney, D I Wang

    Biotechnology and Bioengineering
    |January 1, 1977
    PubMed
    Summary
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    Accurate measurement of yeast cell density is crucial for optimizing fermentation economics. This study demonstrates an indirect method using material balancing and computer monitoring as a viable alternative to direct sensors for industrial yeast production.

    Area of Science:

    • Biotechnology
    • Biochemical Engineering
    • Industrial Microbiology

    Background:

    • Yeast production economics rely on cellular yield and volumetric productivity.
    • Maximizing these requires continuous monitoring of cell density and growth rate.
    • Direct biomass sensors are unavailable for industrial fermentations.

    Purpose of the Study:

    • To evaluate an indirect method for measuring cell density in yeast fermentation.
    • To assess the viability of on-line computer monitoring for process optimization.
    • To provide an alternative to direct biomass sensors in industrial settings.

    Main Methods:

    • Utilized material balancing with on-line computer monitoring.
    • Employed a 14-liter fermentor with a PDP-11/10 computer for real-time analysis.

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  • Estimated cell density using oxygen uptake, carbon dioxide production, gas flow rate, and ammonia addition data.

    • Main Results:

    • The indirect measurement technique proved to be a viable alternative.
    • Estimated cell density correlated well with actual fermentation data.
    • On-line computer monitoring facilitated indirect measurement.

    Conclusions:

    • Material balancing with on-line computer monitoring is a practical approach for estimating yeast cell density.
    • This method supports the optimization of yeast production processes.
    • It offers a feasible solution in the absence of direct biomass sensors.