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Updated: Dec 27, 2025

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Impact of Exogenous Testosterone on Reproduction in Transgender Men
Molly B Moravek1,2, Hadrian M Kinnear3,4, Jenny George1
1Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan.
Abstract:
Studies show that a subset of transgender men desire children; however, there is a paucity of literature on the effect of gender-affirming testosterone therapy on reproductive function. In this manuscript, we will review the process of gender-affirming hormone therapy for transgender men and what is known about ovarian and uterine consequences of testosterone exposure in transgender men; draw parallels with existing animal models of androgen exposure; summarize the existing literature on parenting experiences and desires in transgender people; discuss considerations for assisted reproductive technologies and fertility preservation; and identify gaps in the literature and opportunities for further research.
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