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Compound-based Chinese medicine formula: From discovery to compatibility mechanism
Xin Luan1, Li-Jun Zhang1, Xiao-Qin Li2
1Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Journal of Ethnopharmacology
|February 28, 2020
Summary
Compound-based Chinese medicine formulas (CCMF) offer precise composition and quality control, aligning with traditional medicine
Area of Science:
- Pharmacology and Traditional Chinese Medicine (TCM)
Background:
- Chinese medicine formulas (CMF) have a long history in TCM, applied as crude extracts, compound mixtures, or specific compounds.
- The modern scientific basis of CMF theory requires clarification.
Purpose of the Study:
- To critically evaluate research strategies for investigating compound-based Chinese medicine formulas (CCMF).
Main Methods:
- Systematic literature review across major scientific databases (CNKI, Elsevier, ScienceDirect, PubMed, SpringerLink, Web of Science, Wiley Online).
- Evaluation of research designs including discovery, screening, optimization, and pharmacodynamics models.
- Assessment of target research techniques for compatibility compounds.
Main Results:
- Proposed in vitro multicellular three-dimensional culture or organoid models for CCMF compatibility research optimization.
- Potential to elucidate traditional CMF compatibility theories (e.g., Monarch-Minister-Assistant-Guide) through CCMF research.
Conclusions:
- CCMF provides advantages of exact composition and controllable quality, akin to modern medicines.
- CCMF retains the multi-ingredient, multi-target synergistic characteristics of TCM.
- Challenges remain in the future application and development of CCMF.
