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Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
Published on: February 23, 2020
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Nuclear receptors in abdominal aortic aneurysms.
Jaap G Neels1, Réda Hassen-Khodja2, Giulia Chinetti2
1Université Côte d'Azur, INSERM, C3M, Nice, France.
Atherosclerosis
|February 28, 2020
Summary
Nuclear receptors (NRs) show promise for treating abdominal aortic aneurysms (AAA) by targeting shared pathways with atherosclerosis. This review highlights NRs as potential therapeutic targets to slow AAA growth and prevent rupture.
Area of Science:
- Cardiovascular Medicine
- Molecular Biology
- Pharmacology
Background:
- Abdominal aortic aneurysms (AAA) are a significant health concern with limited non-surgical treatment options.
- AAA shares pathophysiological mechanisms with atherosclerosis, including inflammation and matrix degradation.
- Nuclear receptors (NRs) are implicated in cardiovascular disease (CVD) and atherosclerosis.
Purpose of the Study:
- To review the role of nuclear receptors (NRs) in cardiovascular disease (CVD), focusing on atherosclerosis.
- To discuss the current understanding of NR implications in abdominal aortic aneurysms (AAA).
- To identify potential NR-based therapeutic targets for AAA.
Main Methods:
- Literature review of studies on nuclear receptors in cardiovascular disease and AAA.
- Analysis of shared pathophysiological mechanisms between AAA and atherosclerosis.
- Synthesis of evidence regarding the role of specific NRs in AAA development and progression.
Main Results:
- NRs play significant roles in both CVD and AAA.
- The roles of NRs in AAA often mirror their established functions in atherosclerosis.
- Several NRs demonstrate potential as therapeutic targets for AAA.
Conclusions:
- Nuclear receptors represent promising targets for novel pharmacotherapies for abdominal aortic aneurysms.
- Targeting NRs could offer a strategy to retard AAA expansion and reduce rupture risk.
- Further research into NR-mediated pathways is warranted for AAA treatment development.
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