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Cardiovascular autonomic neuropathy: A silent killer with long reach

Lynn Ang1, Brendan Dillon2, Kara Mizokami-Stout1

  • 1Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, United States of America.

Autonomic Neuroscience : Basic & Clinical
|February 28, 2020
PubMed

Insights

Cardiovascular autonomic neuropathy (CAN), a serious diabetes complication, is often missed. Early detection of CAN is crucial for interventions to prevent progression and reduce risks of heart disease and mortality.

Area of Science:

  • Endocrinology
  • Cardiology
  • Neurology

Background:

  • Cardiovascular autonomic neuropathy (CAN) is a prevalent and serious complication of diabetes mellitus.
  • CAN often presents subtly, leading to delayed diagnosis and missed opportunities for intervention.
  • CAN is linked to increased risks of cardiovascular disease (CVD), arrhythmias, heart failure, and mortality.

Purpose of the Study:

  • To review current epidemiological trends of CAN.
  • To explore novel mechanisms connecting CAN with other diabetic complications.
  • To outline current diagnostic and management recommendations for CAN in clinical practice.

Main Methods:

  • Literature review of current epidemiological data.
  • Analysis of emerging research on pathophysiological links between CAN and diabetes complications.
  • Synthesis of clinical guidelines for CAN diagnosis and management.

Main Results:

  • CAN affects a significant diabetic population and contributes to substantial morbidity and mortality.
  • Emerging evidence reveals intricate links between CAN and other diabetes-related conditions.
  • Established diagnostic criteria and management strategies exist but require wider clinical adoption.

Conclusions:

  • Timely detection and management of CAN are vital for improving outcomes in patients with diabetes.
  • Further research into CAN mechanisms and effective interventions is warranted.
  • Enhanced clinical awareness and adherence to guidelines can mitigate the severe consequences of CAN.
Keywords:
Cardiovascular autonomic dysfunctionCardiovascular autonomic neuropathyCardiovascular diseaseDiabetes mellitus

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