Resistance exercise causes greater serum hepcidin elevation than endurance (cycling) exercise
Kazushige Goto1, Chihiro Kojima2, Nobukazu Kasai2
1Graduate School of Sports and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan.
Plos One
|February 28, 2020
Summary
Resistance exercise significantly elevates hepcidin more than endurance exercise, potentially increasing iron deficiency risk in athletes. Athletes engaging in resistance training should be mindful of this risk.
Area of Science:
- Exercise Physiology
- Sports Medicine
- Endocrinology
Background:
- Hepcidin is a key hormone regulating iron metabolism.
- Elevated hepcidin following exercise is a potential risk factor for iron deficiency in athletes.
Purpose of the Study:
- To compare the serum hepcidin response to resistance exercise versus endurance exercise.
- To investigate the hormonal and inflammatory markers associated with different exercise types.
Main Methods:
- Ten male participants underwent three trials: resistance exercise (RE), endurance exercise (END), and rest (REST).
- Blood samples were collected pre-exercise and up to 6 hours post-exercise.
- Measurements included serum hepcidin, iron, growth hormone, cortisol, myoglobin, lactate, and plasma IL-6.
Main Results:
- Both RE and END increased hepcidin, with significantly greater elevation after RE (463%) compared to END (137%).
- Resistance exercise induced higher increases in blood lactate, growth hormone, and cortisol compared to endurance exercise.
- Serum iron and plasma IL-6 levels increased post-exercise with no significant difference between RE and END.
Conclusions:
- Resistance exercise leads to a more pronounced hepcidin elevation than endurance exercise.
- Athletes participating in regular resistance training may require increased caution to prevent iron deficiency.
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