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Roles of Splicing Factors in Hormone-Related Cancer Progression

Toshihiko Takeiwa1, Yuichi Mitobe1, Kazuhiro Ikeda1

  • 1Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama 350-1241, Japan.

International Journal of Molecular Sciences
|February 29, 2020
PubMed

Insights

Messenger RNA (mRNA) splicing generates diverse protein isoforms, crucial in cancer development. Targeting splicing mechanisms offers a promising new cancer therapy strategy, particularly for hormone-related cancers.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • Alternative splicing of messenger RNA precursors (pre-mRNA) generates multiple mRNA isoforms from a single gene.
  • Aberrant splicing is implicated in various cancers, influencing proliferation, migration, and hormone response.
  • Splicing-targeting therapies represent a novel and promising strategy for cancer treatment.

Purpose of the Study:

  • To review the role of RNA-binding proteins in regulating splicing events.
  • To focus on splicing regulation in hormone-related cancers like breast and prostate cancer.
  • To highlight the potential of splicing-targeting therapies.

Main Methods:

  • Review of existing scientific literature on mRNA splicing and cancer.
  • Analysis of the roles of specific RNA-binding protein families (DBHS, SR proteins, hnRNPs).
  • Focus on splicing alterations in hormone-dependent cancers.

Main Results:

  • Cancer-specific splicing events are integral to cancer progression.
  • RNA-binding proteins, including DBHS, SR proteins, and hnRNPs, are key regulators of these splicing events.
  • Dysregulated splicing in hormone-related cancers impacts key biological processes.

Conclusions:

  • Splicing regulation by RNA-binding proteins is critical in hormone-related cancers.
  • Understanding these mechanisms can lead to the development of targeted cancer therapies.
  • Splicing-targeting strategies hold significant therapeutic potential for breast and prostate cancers.
Keywords:
DBHS family proteinsSR proteinsbreast cancerhnRNPsprostate cancer

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