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The Research on Multi-material 3D Vascularized Network Integrated Printing Technology.

Shuai Yang1,2, Hao Tang1,2, Chunmei Feng1

  • 1School of Electrical and Automation Engineering, Nanjing Normal University, Nanjing 210023, China.

Micromachines
|February 29, 2020
PubMed
Summary

This study introduces a new method for creating 3D perfusable channels using combined extrusion and inkjet bioprinting. This technique advances the in vitro culture of thick tissues by enabling the fabrication of vascularized structures.

Keywords:
drop-based printingextrusion-based printinghydrogelperfusionthree-dimensional bioprintingvascularized channels

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Area of Science:

  • Bioprinting
  • Tissue Engineering
  • Biomaterials

Background:

  • Three-dimensional (3D) bioprinting offers potential for fabricating vascularized channels crucial for in vitro tissue culture.
  • Developing methods for creating perfusable channels is essential for advancing tissue engineering and regenerative medicine.

Purpose of the Study:

  • To report a novel integrated manufacturing process for fabricating 3D perfusable channels.
  • To investigate the theoretical factors influencing the structural dimensions of printed parts.
  • To demonstrate a strategy for creating vascularized channels for culturing thick tissues.

Main Methods:

  • A hybrid approach combining extrusion and inkjet bioprinting techniques was developed.
  • Photocurable hydrogel was printed to form a self-supporting structure with internal channel grooves.
  • A sacrificial material was printed using a piezoelectric nozzle, followed by hydrogel encapsulation and crosslinking with CaCl2 solution.

Main Results:

  • A theoretical model was established to analyze the impact of printing parameters (speed, pressure, time, voltage) on structural dimensions.
  • The integrated process successfully fabricated 3D structures with internal channel grooves.
  • Removal of the sacrificial material resulted in the formation of perfusable channels within the hydrogel construct.

Conclusions:

  • The developed hybrid bioprinting approach provides a viable strategy for fabricating 3D vascularized channels.
  • This method has the potential to significantly advance the development of in vitro culture systems for thick tissues.
  • The ability to create perfusable channels is a key step towards engineering functional, complex tissues.