Related Experiment Video

Updated: Dec 27, 2025

Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol
13:09

Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol

Published on: April 1, 2018

10.8K

Paediatric Rational Prescribing: A Systematic Review of Assessment Tools

Fenella Corrick1, Sharon Conroy1, Helen Sammons1,2

  • 1Division of Medical Sciences & Graduate Entry Medicine, University of Nottingham, Royal Derby Hospital Centre, Uttoxeter Road, Derby DE22 3DT, UK.

International Journal of Environmental Research and Public Health
|February 29, 2020
PubMed

Insights

This review identifies three tools for assessing rational prescribing in children: POPI, modified POPI (UK), and PIPc. These tools aid in improving medication use and guiding research in pediatric pharmacotherapy.

Area of Science:

  • Pharmacology and Therapeutics
  • Pediatric Medicine
  • Health Services Research

Background:

  • Rational prescribing criteria are established in adult medicine but less investigated in pediatrics.
  • Ensuring appropriate medication use in children is crucial for their health outcomes.
  • Existing tools for pediatric rational prescribing require systematic identification and overview.

Purpose of the Study:

  • To identify and review all developed pediatric rational prescribing tools.
  • To provide an overview of the characteristics of these tools.
  • To support quality improvement and research in pediatric pharmacotherapy.

Main Methods:

  • Systematic literature search of MEDLINE, Embase, CINAHL, and IPA until July 2019.
  • Inclusion of all published pediatric rational prescribing tools.
  • Recording of tool characteristics: development method, criteria types, assessed aspects, and practice setting.

Main Results:

  • Three pediatric rational prescribing tools were identified: POPI, modified POPI (UK), and PIPc.
  • POPI and modified POPI (UK) use a mixed approach, while PIPc uses explicit criteria.
  • Tools vary in their intended practice settings and basis of practice standards (French or UK).

Conclusions:

  • This review describes three key tools for assessing rational prescribing in children.
  • The identified tools (POPI, modified POPI (UK), PIPc) offer distinct approaches and applicability.
  • This information can guide the use of these tools in quality improvement initiatives and future research in pediatric rational prescribing.

Keywords:
paediatricsrational prescribingrational use of medicines

More Related Videos

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

6.2K
Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

16.5K

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
189
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
159
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
184
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
146
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
99
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
197