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Updated: Dec 27, 2025

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood
Published on: January 9, 2018
Understanding the tests that we order: screening for anti-NMDA receptor encephalitis in first episode psychosis
Joel Singer1, Perminder Sachdev2,3,1, Adith Mohan3,4,1
1Neuropsychiatric Institute, Prince of Wales Hospital, Australia.
Objective:
The current guidelines recommend screening all patients with first episode psychosis (FEP) for anti-NMDA receptor encephalitis. This paper explores the pitfalls of this strategy.
Conclusion:
Screening for anti-NMDA receptor encephalitis in patients with FEP when the pre-test probability based on the clinical presentation is low creates a risk of false positive results. Testing based on clinical suspicion would be preferable.
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