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Association between prepregnancy subnormal body weight and obstetrical outcomes after autologous in vitro
Yi-Quan Xiong1, Yan-Mei Liu1, Ya-Na Qi1
1Chinese Evidence-Based Medicine Center and CREAT Group, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Objective:
To study the association between prepregnancy subnormal body weight and obstetrical outcomes after autologous in vitro fertilization (IVF) cycles.
Design:
Systematic review and meta-analysis.
Setting:
Not applicable.
Patient(S):
Women with prepregnancy subnormal body weight (body mass index <18.5 kg/m2) and normal body weight (body mass index 18.5-25 kg/m2) after assisted reproductive treatment.
Interventions(S):
None.
Main Outcome Measure(S):
Clinical pregnancy rate (CPR), live birth rate (LBR), and miscarriage rate. CPR and LBR were calculated at per-woman and per-cycle levels.
Result(S):
A total of 38 cohort studies with low risk of bias were included. Meta-analyses showed that, compared with normal-weight women, those underweight before pregnancy had a lower CPR at per-woman and per-cycle levels. Compared with normal weight, underweight before pregnancy had little impact on LBR at both per-woman and per-cycle levels, nor on miscarriage rate.
Conclusion(S):
Compared with women of normal weight, women who were underweight before pregnancy had modest association with a lower CPR, but underweight did not seem to affect LBR or miscarriage after IVF.
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