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Updated: Dec 27, 2025

Microwave-assisted Intramolecular Dehydrogenative Diels-Alder Reactions for the Synthesis of Functionalized Naphthalenes/Solvatochromic Dyes
Published on: April 1, 2013
Amplification of the chiroptical response of UV-transparent amines and alcohols by N-phthalimide derivatization
Daniele Padula1, Giuseppe Mazzeo, Ernesto Santoro
1Dipartimento di Scienze, Università della Basilicata, via dell'Ateneo Lucano, 85100, Potenza, Italy. stefano.superchi@unibas.it.
Abstract:
The stereoselective transformation of chiral UV-transparent amines and alcohols to phthalimides has proved to be a simple and efficient method to enhance the chiroptical response of these substrates allowing their reliable absolute configuration determination by computational analysis of ECD spectra. Such a transformation also leads to a significant reduction in the molecular conformational flexibility thus simplifying the conformational analysis required by the computational treatment. The method described herein thus allows the absolute configuration assignment to these challenging substrates to be much easier and reliable.
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