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Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
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Penicillin Allergy Testing Is Cost-Saving: An Economic Evaluation Study.

Bernardo Sousa-Pinto1,2,3, Kimberly G Blumenthal4,5, Eric Macy6

  • 1Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|February 29, 2020
PubMed
Summary
This summary is machine-generated.

Penicillin allergy testing is cost-saving for patients with a penicillin allergy label. Widespread testing can reduce healthcare costs and improve antibiotic appropriateness.

Keywords:
drug allergydrug challengeeconomic evaluationpenicillin allergy

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Area of Science:

  • Health Economics
  • Clinical Allergy
  • Pharmacoeconomics

Background:

  • A penicillin allergy label is linked to suboptimal and costly antibiotic use.
  • Penicillin allergy testing can identify individuals who are not truly allergic.
  • This can lead to significant cost savings in healthcare.

Purpose of the Study:

  • To project the cost-effectiveness of penicillin allergy testing.
  • To evaluate diagnostic testing versus no testing in patients with a penicillin allergy label.

Main Methods:

  • Economic evaluation using decision models.
  • Considered strategies: diagnostic testing (skin tests/drug challenges) vs. no testing.
  • Modeled costs including tests, hospitalizations, outpatient visits, and antibiotic use.

Main Results:

  • Penicillin allergy testing was cost-saving in all modeled scenarios.
  • Average savings ranged from $657 (inpatients) to $2746 (outpatients).
  • Probabilistic sensitivity analysis indicated testing as the less costly option in 75% of simulations.

Conclusions:

  • Penicillin allergy testing is projected to be cost-saving across various settings.
  • Supports the implementation of policies for widespread penicillin allergy testing.
  • Aims to improve antibiotic stewardship and reduce healthcare expenditures.