Related Experiment Video
Updated: Dec 27, 2025
Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
Tumor Mutational Patterns and Infiltrating Lymphocyte Density in Young and Elderly Patients With Breast Cancer
Adamantia Nikolaidi1, Vassiliki Kotoula2,3, Georgia-Angeliki Koliou4
1Oncology Department Mitera Hospital, Athens, Greece mantonikolaidi@gmail.com hecogoff@otenet.gr.
Background/Aim:
Age may pertain to different tumor genotype characteristics which may interfere with treatment efficacy and prognosis. We investigated the distribution and prognostic effect of mutations and tumor infiltrating lymphocyte (stromal TIL density) in young (≤35 years) and elderly (>65 years) early breast cancer patients.
Materials And Methods:
Paraffin tumor genotypes of all clinical subtypes from 345 patients were examined.
Results:
A total of 638 mutations were detected in 221 patients (64.1%). Compared to young, elderly patients presented with lower TIL density (p<0.001) but more TILs in TP53 mutated tumors (p=0.042). Mutation in one, rather than in 2 or more genes, conferred better outcome (DFS: HR=0.51, p=0.016; OS: HR=0.47, p=0.015) but the effect was age-independent.
Conclusion:
There are fewer TILs and different mutations patterns in tumors from elderly patients compared to young. Age and TIL-independent gene agnostic co-mutations affect patient outcome.
More Related Videos
09:32Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
Published on: February 8, 2018
08:32Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
Published on: June 7, 2018