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Updated: Dec 27, 2025

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
Published on: February 17, 2023
Insulin resistance negatively affects bone quality not quantity: the relationship between bone and adipose tissue
I M de Araújo1, L T Parreiras-E-Silva1, A L Carvalho1
1Department of Internal Medicine, Ribeirão Preto Medical School, USP, 3900 Bandeirantes Avenue, Ribeirao Preto, SP, 14049-900, Brazil.
Insulin resistance does not affect bone quantity, but negatively impacts bone quality, as indicated by the trabecular bone score. This suggests the trabecular bone score may help evaluate osteoporosis risk in insulin-resistant individuals.
Area of Science:
- Metabolic bone disease
- Endocrinology
- Radiology
Background:
- Conflicting literature exists on insulin resistance's effect on bone health.
- This study investigates the relationship between insulin resistance, adipose tissue, and bone health metrics.
Purpose of the Study:
- To evaluate the association of insulin resistance and adipose tissue with bone mineral density (BMD) and trabecular bone score (TBS).
Main Methods:
- 56 participants (36 women, 20 men) underwent biochemical tests.
- Bone assessment included dual-X-ray absorptiometry for BMD and TBS.
- Magnetic resonance imaging estimated adipose tissue depots and intrahepatic lipids.
Main Results:
- BMD showed no association with insulin resistance markers (visceral adipose tissue, intrahepatic lipids, HOMA-IR).
- TBS demonstrated a negative association with insulin resistance markers and visceral adipose tissue.
- Marrow adipose tissue negatively correlated with both BMD and TBS.
Conclusions:
- Trabecular bone score is negatively associated with insulin resistance, visceral adipose tissue, and intrahepatic lipids.
- Marrow adipose tissue, particularly saturated lipids, shows a negative relationship with TBS.
- Further research is warranted to explore TBS in assessing osteoporosis in insulin-resistant states.
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