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Updated: Dec 27, 2025

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
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Cell-substrate mechanics guide collective cell migration through intercellular adhesion: a dynamic finite element

Jieling Zhao1, Farid Manuchehrfar2, Jie Liang2

  • 1INRIA de Paris and Sorbonne Universités UPMC, LJLL Team Mamba, Paris, France. jieling.zhao@inria.fr.

Biomechanics and Modeling in Mechanobiology
|February 29, 2020
PubMed
Summary

Cell-substrate mechanics guide collective cell migration through cell protrusion and intercellular adhesions, crucial for tissue regeneration and wound healing processes.

Keywords:
Cell–substrate mechanicsCollective cell migrationDyCelFEMFinite element modelIntercellular adhesion

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Area of Science:

  • Biophysics
  • Cell Biology
  • Computational Biology

Background:

  • Collective cell migration is vital for tissue formation, regeneration, and wound healing.
  • The precise roles of cell-substrate and cell-cell mechanical interactions in regulating this process remain incompletely understood.

Purpose of the Study:

  • To investigate the influence of mechanical feedback between cells and their substrate, and mechanical signal transmission between cells on collective cell migration.
  • To explore the mechano-chemical feedback loop involving cell-substrate mechanics and Rac-mediated cell protrusion.

Main Methods:

  • Development of a high-resolution, finite element cellular model using triangular elements.
  • Explicit modeling of cadherin adhesion between cells as subcellular linear springs.
  • Incorporation of a mechano-chemical feedback loop linking cell-substrate mechanics to cell protrusion.

Main Results:

  • The model successfully reproduced experimentally observed collective cell migration patterns, including migration persistence, cell pair separation, and directionality during wound healing.
  • Cell protrusion, regulated by cell-substrate mechanics, was identified as a key factor in guiding persistent and oriented collective cell migration.
  • Intercellular adhesions were shown to maintain and transmit these guidance cues to distant cells.

Conclusions:

  • The developed finite element model provides a powerful tool for studying complex tissue dynamics at the subcellular level.
  • Cell-substrate mechanics and intercellular adhesions play critical roles in orchestrating collective cell migration during tissue regeneration.