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Retraction: Hsa_circ_0003645 shows an oncogenic role by sponging microRNA-1299 in hepatocellular carcinoma cells

Qiuyun Yu1, Jinhua Dai1, Ming Shu2

  • 1Department of Clinical Laboratory, Hwa Mei Hospital, University of Chinese Academy of Science (Ningbo No.2 Hospital), Ningbo, China.

Journal of Clinical Laboratory Analysis
|February 29, 2020
PubMed

Insights

This study on hepatocellular carcinoma cells is retracted due to flawed data and unreliable conclusions. The original data for Hsa_circ_0003645 and microRNA-1299 is unavailable, preventing verification of findings.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Hepatocellular carcinoma (HCC) is a significant global health concern.
  • Circular RNAs (circRNAs) are increasingly recognized for their roles in cancer development.
  • Hsa_circ_0003645 was previously proposed to play an oncogenic role in HCC by sponging microRNA-1299.

Purpose of the Study:

  • To investigate the role of Hsa_circ_0003645 in hepatocellular carcinoma.
  • To explore the interaction between Hsa_circ_0003645 and microRNA-1299 in HCC cells.

Main Methods:

  • Analysis of data and figures presented in the original study.
  • Evaluation of the reliability of presented experimental results.

Main Results:

  • The data and figures, including Figure 7A, presented in the original publication are flawed.
  • The original data supporting the study's conclusions are not available.
  • The conclusions drawn from the presented data are unreliable.

Conclusions:

  • The findings regarding the oncogenic role of Hsa_circ_0003645 and its interaction with microRNA-1299 in hepatocellular carcinoma cells are unsubstantiated.
  • The retraction highlights the importance of data integrity and reproducibility in scientific research.

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