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Severe uncontrolled asthma in children: practical approach on diagnosis and management

Riccardo Castagnoli1, Alessia Marseglia1, Ilaria Brambilla1

  • 1Department of Pediatrics, Pediatric Clinic, Policlinico San Matteo IRCCS Foundation, University of Pavia, Pavia, Italy.

Minerva Pediatrica
|February 29, 2020
PubMed

Insights

Severe uncontrolled asthma in children presents significant challenges. This review updates knowledge on diagnosing and managing severe pediatric asthma, including personalized therapies for better outcomes.

Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology
  • Clinical Medicine

Background:

  • Severe uncontrolled asthma in children is a heterogeneous condition posing significant challenges.
  • Affected children experience persistent symptoms, severe exacerbations, medication side effects, and reduced quality of life.
  • These patients incur higher healthcare costs and resource utilization.

Purpose of the Study:

  • To provide an updated review on the diagnosis and management of severe uncontrolled asthma in childhood.
  • To differentiate between difficult-to-treat and true severe therapy-resistant asthma in pediatric patients.
  • To analyze current personalized therapies for severe pediatric asthma based on pathogenetic mechanisms.

Main Methods:

  • Literature review focusing on recent advances in severe pediatric asthma.
  • Discussion of diagnostic approaches and differentiation strategies.
  • Analysis of approved precision medicine therapies for pediatric indications.

Main Results:

  • Severe asthma requires accurate definition and diagnosis for appropriate management.
  • Understanding pathogenetic mechanisms enables a precision medicine approach.
  • Personalized therapies are emerging as a key strategy for severe uncontrolled asthma.

Conclusions:

  • Accurate diagnosis is crucial for managing severe uncontrolled asthma in children.
  • Precision medicine, guided by pathogenetic insights, offers new therapeutic avenues.
  • This review provides a practical guide for clinicians managing severe pediatric asthma.

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