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Related Experiment Videos

Genetically determined differences in ethanol sensitivity influenced by body temperature during intoxication.

R L Alkana1, D A Finn, M Bejanian

  • 1Institute for Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033.

Life Sciences
|January 1, 1988
PubMed
Summary

Body temperature significantly influences ethanol

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Genetics

Background:

  • Ethanol's hypnotic effects vary across mouse strains.
  • Body temperature changes during intoxication are not fully understood.
  • Investigating environmental factors influencing ethanol sensitivity is crucial.

Purpose of the Study:

  • To determine the role of body temperature in ethanol-induced hypnotic effects.
  • To analyze strain-specific differences in ethanol sensitivity.
  • To elucidate the interaction between environmental temperature and ethanol pharmacokinetics.

Main Methods:

  • Five inbred mouse strains (C57BL/6J, BALB/cJ, DBA/2J, A/HeJ, 129/J) were used.
  • Mice were exposed to ethanol and then maintained at either 22°C or 34°C.

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  • Rectal temperature, duration of loss of righting reflex (LORR), and ethanol concentrations in blood and brain were measured.

    • Main Results:

    • Exposure to 22°C led to hypothermia and significant strain differences in temperature, LORR, and ethanol concentrations.
    • Exposure to 34°C counteracted hypothermia, reducing strain-related differences.
    • Offsetting hypothermia at 34°C increased ethanol sensitivity in some strains, indicated by lower brain ethanol concentrations at the return of righting reflex (RORR).

    Conclusions:

    • Genetically determined ethanol sensitivity is influenced by body temperature during intoxication.
    • Environmental temperature plays a critical role in mediating ethanol's behavioral effects.
    • Differences in ethanol sensitivity involve both body temperature regulation and cellular-level responses.