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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

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Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
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Biological Methods for Microbial Control01:28

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Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
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Antimicrobial Proteins01:23

Antimicrobial Proteins

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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
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Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

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Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
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Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

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The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
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Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods
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Proteobiotics as a new antimicrobial therapy.

Brianna Tarsillo1, Ronny Priefer1

  • 1Massachusetts College of Pharmacy and Health Sciences University, Boston, MA, USA.

Microbial Pathogenesis
|February 29, 2020
PubMed
Summary

Proteobiotics, or probiotic-derived metabolites, offer a novel strategy to combat antibiotic resistance by disrupting bacterial communication. This approach shows promise in preventing infections and reducing healthcare costs.

Keywords:
Antibiotic resistancePathogenesisProteobioticsVirulence

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Area of Science:

  • Microbiology
  • Pharmacology
  • Human Microbiome Research

Background:

  • Antibiotic resistance is a significant global health threat, increasing patient morbidity, mortality, and healthcare expenses.
  • Inhibiting bacterial virulence factors offers a potential strategy to manage infections and mitigate the development of further resistance.
  • The human microbiome and its associated metabolites are increasingly explored for novel therapeutic compounds.

Purpose of the Study:

  • To explore the potential of proteobiotics, metabolites from probiotics, as an alternative strategy against antibiotic resistance.
  • To investigate the mechanism of action of proteobiotics in disrupting bacterial pathogenesis.
  • To highlight the therapeutic implications of proteobiotics in clinical settings.

Main Methods:

  • Review of existing literature on antibiotic resistance, virulence factors, and probiotics.
  • Identification and characterization of novel antimicrobial compounds derived from probiotics (proteobiotics).
  • Analysis of proteobiotics' ability to interfere with bacterial cell-to-cell communication.

Main Results:

  • Proteobiotics have demonstrated antimicrobial activity.
  • Proteobiotics effectively interrupt bacterial communication pathways.
  • A commercially available product utilizing proteobiotic technology has shown positive results in swine.

Conclusions:

  • Proteobiotics represent a promising avenue for combating antibiotic resistance.
  • Targeting bacterial virulence through proteobiotics can reduce pathogenesis and prevent resistance.
  • Further research and application of proteobiotics hold significant potential for human and animal health.