Heteroleptic NiII complexes: Synthesis, structural characterization, computational studies and amoebicidal activity
Luis Felipe Hernández-Ayala1, Yanis Toledano-Magaña1, Luis Ortiz-Frade2
1Departamento de Química Inorgánica y Nuclear, Facultad de Química, UNAM, Ciudad Universitaria, Ciudad de México, Mexico.
Journal of Inorganic Biochemistry
|February 29, 2020
Summary
Seven new nickel coordination compounds were synthesized and tested for amoebicidal activity. The most effective compound, with the largest molar volume, significantly outperformed metronidazole against Entamoeba histolytica.
Area of Science:
- Coordination Chemistry
- Medicinal Inorganic Chemistry
- Parasitology
Background:
- Amoebiasis, caused by Entamoeba histolytica, remains a significant global health concern.
- Development of novel therapeutic agents is crucial, as current treatments face challenges.
- Metal-based compounds, particularly nickel(II) complexes, show promise as antiparasitic agents.
Purpose of the Study:
- To synthesize and characterize novel heteroleptic Ni(II) coordination compounds.
- To evaluate the in vitro amoebicidal activity of these compounds against Entamoeba histolytica.
- To investigate the structure-activity relationship between compound properties and antiparasitic efficacy.
Main Methods:
- Synthesis and structural characterization of seven Ni(II) coordination compounds.
- Electrochemical studies (redox potential, diffusion coefficients) and DFT calculations (molar volume, electron density).
- In vitro testing of amoebicidal activity and measurement of reactive oxygen species (ROS) generation.
Main Results:
- The crystal structures of two representative compounds were determined.
- The 5,6-dimethyl-1,10-phenanthroline (56dmphen) derivative exhibited potent amoebicidal activity (IC50 = 1.2 μM), seven times more effective than metronidazole.
- Increased molar volume and ROS concentration correlated with enhanced amoebicidal activity, while more positive redox potentials decreased efficacy.
Conclusions:
- The synthesized Ni(II) complexes demonstrate significant potential as novel amoebicidal agents.
- Molar volume and ROS generation are key factors influencing the antiparasitic efficacy of these compounds.
- This study provides valuable insights into the design of effective metal-based drugs for treating amoebiasis.
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