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The 95% effective dose of intranasal dexmedetomidine sedation for pulmonary function testing in children aged

Shangyingying Li1, Hui Liu2, Jing Zhang2

  • 1Department of Anesthesiology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; National Clinical Research Center for Child Health and Disorders, Chongqing 400014, China; Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.

Journal of Clinical Anesthesia
|February 29, 2020
PubMed

Insights

The 95% effective dose (ED95) of intranasal dexmedetomidine for sedating young children during pulmonary function testing is 2.64 μg/kg. This study determined the optimal intranasal dexmedetomidine dose for pediatric PFT sedation.

Area of Science:

  • Pediatric Anesthesiology
  • Pharmacology
  • Respiratory Medicine

Background:

  • Intranasal dexmedetomidine (DEX) is used for pediatric sedation.
  • Data on the 95% effective dose (ED95) for pediatric pulmonary function testing (PFT) is lacking.

Purpose of the Study:

  • To determine the ED95 of intranasal DEX for children aged 1-3 years undergoing PFT.
  • To evaluate the safety and efficacy of intranasal DEX for this specific pediatric population and procedure.

Main Methods:

  • Prospective study utilizing a biased coin design up-and-down sequential method.
  • Enrolled children aged 1-3 years undergoing PFT, with doses adjusted based on previous patient responses.
  • Assessed sedation using the Modified Observer Assessment of Alertness and Sedation (MOAA/S) scale and recovery using the modified Aldrete score.

Main Results:

  • The study included 68 children, with 62 achieving successful sedation.
  • The estimated ED95 for intranasal DEX was 2.64 μg/kg (95% CI, 2.49-2.87 μg/kg).
  • No adverse events were reported, including hypotension, bradycardia, or respiratory depression.

Conclusions:

  • The ED95 of intranasal DEX for sedating children aged 1-3 years during PFT is 2.64 μg/kg.
  • Intranasal DEX provides effective and safe sedation for pediatric PFT.
Abstract

Keywords:
ED(95)InfantIntranasal dexmedetomidinePulmonary function testingSedation

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