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Electrospraying Oxygen-Generating Microparticles for Tissue Engineering Applications.

Alan Is Morais1, Xichi Wang2,3,4, Ewerton G Vieira1

  • 1LIMAV-Interdisciplinary Laboratory for Advanced Materials, Materials Science and Engineering Graduate Program, UFPI-Federal University of Piauí, Teresina, PI CEP 64049-550, Brazil.

International Journal of Nanomedicine
|February 29, 2020
PubMed
Summary
This summary is machine-generated.

New oxygen-generating microparticles (M) composed of Polycaprolactone (PCL), Pluronic F-127, and calcium peroxide (CPO) promote cell growth and viability, showing promise for tissue engineering applications.

Keywords:
calcium peroxidecartilageelectrosprayingoxygen-generating-microparticlestissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Development of novel oxygen-generating microparticles (M) using Polycaprolactone (PCL), Pluronic F-127, and calcium peroxide (CPO).
  • Fabrication of these PCL-F-CPO-M via an electrospraying process for facile preparation.
  • Established the potential of these microparticles in enhancing cell growth and viability.

Purpose of the Study:

  • To characterize the fabricated oxygen-generating microparticles (PCL-F-CPO-M).
  • To evaluate the biological impact of these microparticles on cell viability and growth.
  • To assess the sustained oxygen release capability of the microparticles.

Main Methods:

  • Electrospraying technique for microparticle fabrication.
  • Characterization using X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and Scanning Electron Microscopy (SEM)/SEM-Energy Dispersive Spectroscopy (EDS).
  • Biological assessment using rat chondrocytes to evaluate cell viability and growth.

Main Results:

  • Confirmation of component presence and porous structure in microparticles via analytical techniques.
  • Obtained spherical, spongy microparticles with a negative surface charge (ζ = -16.9) and size of 17.00 ± 0.34 μm.
  • Demonstrated good cell viability and a positive correlation between CPO concentration and beneficial effects on rat chondrocytes.

Conclusions:

  • The developed technological platform yields oxygen-generating microparticles (PCL-F-CPO-M) with sustained oxygen release for up to 7 days.
  • These microparticles significantly enhance cell viability, making them valuable for tissue engineering.
  • The facile fabrication and positive biological outcomes position this technology for broad biomedical applications.