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Biochemical diagnosis of genetic disorders of the osseous skeleton
1Department of Orthopaedics, College of Medicine, University of Illinois, Chicago 60680.
Medical Hypotheses
|November 1, 1988
Abstract:
Genetic diseases of the skeletal system are difficult to accurately diagnose. Changes in the chemical structure of collagen significantly modify the structure of collagen in bone. The ratio of collagen hydration to hydroxylation reflects specific features of the collagen structure. The hypothesis proposes to use this ratio in the diagnosis of diseases of the skeleton.