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A Tailored HPLC Purification Protocol That Yields High-purity Amyloid Beta 42 and Amyloid Beta 40 Peptides, Capable of Oligomer Formation
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Twists or turns: stabilising alpha vs. beta turns in tetrapeptides

Huy N Hoang1, Timothy A Hill1, Gloria Ruiz-Gómez1,2

  • 1Australian Research Council Centre of Excellence in Advanced Molecular Imaging , Institute for Molecular Bioscience , The University of Queensland , Brisbane , QLD 4072 , Australia .

Chemical Science
|February 29, 2020
PubMed
Summary

Cyclic tetrapeptides were synthesized to mimic protein hotspots, revealing specific amino acid sequences stabilize beta, gamma, or alpha turns. These findings offer insights into the structural stability of non-regular protein folds.

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