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Antibiotic Susceptibility of Bacterial Agents Causing Meningitis in Children Older than 1 Month

Reihaneh Mohsenipour1, Behdad Gharib2, Hamid Eshaghi2

  • 1Department of Pediatric Endocrinology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Drug Research
|February 29, 2020
PubMed

Insights

This study analyzed bacterial meningitis in children, finding Staphylococcus epidermidis most common. Results highlight the need to understand common pathogens and antibiotic resistance in pediatric meningitis cases.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Bacterial meningitis remains a significant cause of childhood morbidity and mortality.
  • Understanding the etiological agents and their antibiotic susceptibility patterns is crucial for effective treatment and infection control.

Purpose of the Study:

  • To determine the frequency and antibiotic susceptibility of bacterial meningitis pathogens in children over one month old.
  • To identify common and rare bacterial causes of meningitis and their resistance profiles.

Main Methods:

  • Cerebrospinal fluid (CSF) samples were collected from pediatric patients between 2012 and 2017.
  • Bacterial cultures were performed using chocolate agar, blood agar, and MacConkey agar.
  • Antimicrobial susceptibility testing was conducted using the disc diffusion method.

Main Results:

  • Out of 72 positive bacterial infections, Staphylococcus epidermidis was the most frequent isolate (20.8%).
  • Enterobacter and Pseudomonas aeruginosa were the least common isolates (1.4% each).
  • The majority of affected children were under one year of age, with a higher incidence in males (58.3%) compared to females (41.7%).

Conclusions:

  • Staphylococcus epidermidis and Staphylococcus aureus were the most prevalent bacteria causing meningitis in this pediatric cohort.
  • Escherichia coli and Pseudomonas aeruginosa were infrequently identified.
  • The findings are significant for hospitalized patients, as these bacteria can also cause nosocomial infections.

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