Related Experiment Video
Updated: Dec 27, 2025

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters
Blessing D Mkhonazi1, Malibongwe Shandu1, Ronewa Tshinavhe1
1Research Centre in Synthesis and Catalysis, Department of Chemical Science, University of Johannesburg, PO Box 524, Auckland Park 2006, South Africa.
Abstract:
Amide functional groups are prominent in a broad range of organic compounds with diverse beneficial applications. In this work, we report the synthesis of these functional groups via an iron(iii) chloride-catalyzed direct amidation of esters. The reactions are conducted under solvent-free conditions and found to be compatible with a range of amine and ester substrates generating the desired amides in short reaction times and good to excellent yields at a catalyst loading of 15 mol%.
More Related Videos
06:31Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators
Published on: November 27, 2015
07:56Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron
Published on: August 12, 2019
Related Concept Videos
Acid Halides to Esters: Alcoholysis
Carboxylic Acids to Esters: Acid-Catalyzed (Fischer) Esterification Mechanism
Esters to β-Ketoesters: Claisen Condensation Mechanism
Carboxylic Acids to Esters: Acid-Catalyzed (Fischer) Esterification Overview
Esters to Carboxylic Acids: Acid-Catalyzed Hydrolysis
During hydrolysis, the ester is first activated towards nucleophilic attack through the protonation of the carboxyl oxygen atom by the acid catalyst. The protonation makes the ester carbonyl carbon more electrophilic. In the next step, water acts as a nucleophile and adds to the...
β-Dicarbonyl Compounds via Crossed Claisen Condensations