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Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Notch Signaling Pathway03:14

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Determination01:51

Determination

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During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
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Tooth Anatomy01:21

Tooth Anatomy

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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
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Teeth01:15

Teeth

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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
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Related Experiment Video

Updated: Dec 27, 2025

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
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Sonic Hedgehog Signaling and Tooth Development.

Akihiro Hosoya1, Nazmus Shalehin1, Hiroaki Takebe1

  • 1Division of Histology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan.

International Journal of Molecular Sciences
|March 1, 2020
PubMed
Summary
This summary is machine-generated.

Sonic hedgehog (Shh) signaling is crucial for mammalian tooth development, regulating enamel, dentin, and cementum formation. Gli1-positive cells, downstream of Shh, exhibit stem cell properties aiding in tooth regeneration.

Keywords:
Gli1epithelial and mesenchymal interactionlineage tracing analysismesenchymal stem cellsonic hedgehogstem cell markertooth development

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Author Spotlight: Understanding Dynamic Cellular Behaviors in Adult Mouse Dental Tissue Renewal and Repairment
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Area of Science:

  • Developmental Biology
  • Regenerative Medicine
  • Oral Biology

Background:

  • Sonic hedgehog (Shh) is a key secreted protein in mammalian embryogenesis.
  • Shh signaling is active throughout tooth development, from initiation to root formation.
  • Shh primarily acts within the dental epithelium during tooth development.

Purpose of the Study:

  • To review recent advances in understanding Shh signaling in tooth development.
  • To explore the role of Shh in tooth homeostasis and regeneration.
  • To highlight the function of Gli1-positive cells in dental tissue regeneration.

Main Methods:

  • Literature review of studies on Shh signaling in tooth development.
  • Analysis of Shh expression patterns during different tooth formation stages.
  • Investigation of Gli1-positive cell properties and regenerative potential.

Main Results:

  • Shh signaling regulates the formation of multiple tooth components (enamel, dentin, cementum).
  • Gli1-positive dental mesenchymal cells demonstrate multipotency and self-renewal.
  • These Gli1-positive cells contribute to the regeneration of dental pulp and periodontal tissues.

Conclusions:

  • Shh signaling is essential for normal tooth development and tissue formation.
  • Gli1-positive cells represent a valuable target for dental regenerative therapies.
  • The Shh pathway plays a significant role in maintaining tooth homeostasis and facilitating regeneration.