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Updated: Dec 27, 2025

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
Published on: April 7, 2023
Glucose signaling in the brain and periphery to memory
Md Shamim Hossain1, Yutaka Oomura1, Takehiko Fujino2
1Department of Neuroinflammation and Brain Fatigue Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Abstract:
Glucose has many diverse physiological roles such as energy metabolism, appetite control and memory consolidation. We recently reported that memory-related gene expression is epigenetically controlled in murine brain cells and that glucose can regulate gene expression in a cell-specific manner. However, the literature reviews have indicated that glucose can also regulate gut cells to release incretins which might play a role in memory processes directly or indirectly by vagus nerve stimulation. In this review, we discussed the effects of glucose on the gut and brain, aiming to understand more in-depth the role of glucose in memory function. In addition, we also discussed the alteration of glucose-signaling in type-2 diabetes mellitus (T2DM) and a possible link to Alzheimer's disease (AD) pathologies.
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