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Updated: Dec 27, 2025

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Biliary Excretion Noted on Hepatobiliary Iminodiacetic Acid Scan Does Not Exclude Diagnosis of Biliary Atresia

Adebowale Adeyemi1, Lisa States2, Leslie Wann3

  • 1Division of Gastroenterology, Hepatology and Nutrition, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE.

The Journal of Pediatrics
|March 1, 2020
PubMed

Insights

Hepatobiliary iminodiacetic acid (HIDA) scans can misdiagnose biliary atresia in infants. Misinterpreted scans delay crucial surgical intervention for this serious liver condition.

Area of Science:

  • Pediatric Gastroenterology
  • Diagnostic Imaging
  • Hepatology

Background:

  • Biliary atresia is a severe neonatal liver disease requiring timely surgical intervention.
  • Hepatobiliary iminodiacetic acid (HIDA) scans are commonly employed to assess for biliary patency in cholestatic infants.
  • Accurate diagnosis is critical to prevent irreversible liver damage.

Observation:

  • This study reviewed 6 cases of infants with confirmed biliary atresia.
  • All infants in the study initially showed reported biliary patency on HIDA scans.
  • These findings highlight a potential discrepancy in HIDA scan interpretation.

Findings:

  • Misinterpretation of HIDA scans occurred in infants later diagnosed with biliary atresia.
  • False-negative HIDA scan results can mask the presence of biliary atresia.
  • Diagnostic errors led to significant delays in surgical management.

Implications:

  • Delayed diagnosis of biliary atresia can negatively impact surgical outcomes.
  • There is a critical need for improved HIDA scan interpretation protocols in pediatric cholestasis.
  • Enhanced diagnostic accuracy is essential for optimizing treatment for infants with biliary atresia.

Keywords:
HIDA scanbiliary atresiahepatobiliary scintigraphy

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