Related Experiment Video

Updated: Dec 27, 2025

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

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Management of Patients With Metastatic Renal Cell Cancer and Bone Metastases

Carsten Nieder1,2, Astrid Dalhaug3,2, Adam R Pawinski3

  • 1Department of Oncology and Palliative Medicine, Nordland Hospital, Bodø, Norway carsten.nieder@nlsh.no.

In Vivo (Athens, Greece)
|March 1, 2020
PubMed
Abstract

Insights

Patients with metastatic renal cell cancer (mRCC) and bone metastases face a poor prognosis. Survival is significantly worse if bone metastases are present at initial treatment.

Area of Science:

  • Oncology
  • Medical Research

Background:

  • Metastatic renal cell cancer (mRCC) with bone metastases is associated with poorer patient prognosis.
  • Skeletal involvement impacts survival outcomes in mRCC patients.

Purpose of the Study:

  • To analyze the management and outcomes of mRCC patients with bone metastases.
  • To evaluate the prognostic significance of bone metastasis timing in mRCC.

Main Methods:

  • Retrospective study of 35 consecutive mRCC patients with bone metastases.
  • Systemic treatment, primarily targeted therapy, was analyzed.

Main Results:

  • Median overall survival was 25 months from mRCC diagnosis; 5-year survival was 16%.
  • Patients with bone metastases at first-line therapy start had significantly worse survival (13 months) vs. delayed metastases (46 months).
  • Few patients (29%) received >2 lines of therapy; bone-only metastases were uncommon (11%).

Conclusions:

  • Most mRCC patients with bone metastases have limited overall survival.
  • Early bone metastasis presentation negatively impacts survival in mRCC.
Keywords:
Metastatic renal cell cancerbone metastasesprognosisrural caresystemic therapy

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