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Updated: Dec 27, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
D-Amino acids and kidney diseases
Tomonori Kimura1,2,3, Atsushi Hesaka4,5,6, Yoshitaka Isaka6
1KAGAMI Project, National Institute of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan. t-kimura@nibiohn.go.jp.
D-serine, a D-amino acid, shows promise in managing kidney diseases by correlating with kidney function and disease progression. Measuring blood and urine D-serine aids in early detection and monitoring of kidney conditions.
Area of Science:
- Biochemistry
- Nephrology
- Clinical Diagnostics
Background:
- D-amino acids are enantiomers of L-amino acids with emerging roles in medicine.
- Kidney disease management faces challenges in estimation, diagnosis, and monitoring.
- D-serine is identified as a potential biomarker for kidney function and disease.
Purpose of the Study:
- To explore the potential of D-amino acids, specifically D-serine, in addressing critical issues in chronic and acute kidney disease management.
- To investigate the utility of measuring blood and urinary D-serine levels for assessing kidney function and detecting kidney diseases.
Main Methods:
- Correlation analysis of blood D-serine levels with glomerular filtration rate (GFR).
- Evaluation of urinary D-serine excretion patterns in relation to kidney disease.
- Assessment of chiral-selectivity in serine reabsorption by kidney proximal tubules.
Main Results:
- Blood D-serine levels demonstrate a strong correlation with kidney function (GFR).
- Urinary D-serine excretion is sensitive to the presence of kidney diseases due to inefficient reabsorption compared to L-serine.
- The intra-body dynamics of D-serine (blood levels and urinary excretion) can reflect kidney pathophysiology.
Conclusions:
- Measuring the intra-body dynamics of D-serine offers a novel approach for kidney disease detection and assessment.
- D-serine holds significant potential for improving the comprehensive management of kidney diseases.
- This biomarker can aid in estimating kidney function, early diagnosis, prognosis, and monitoring of kidney conditions.
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