Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

3.3K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
3.3K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

6.0K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.0K
Bacterial Phylum Chlamydiae01:29

Bacterial Phylum Chlamydiae

350
The phylum Chlamydiae or Chlamydiota is composed of a single order, Chlamydiales. This phylum consists entirely of obligate intracellular parasites that infect eukaryotic hosts. While human pathogens within this group have been studied extensively, the phylum encompasses many species capable of interacting with various eukaryotic organisms. Members of Chlamydiae are typically small cocci, approximately 0.5 μm in diameter, and exhibit a distinctive developmental cycle. As is characteristic...
350
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

348
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
348
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

367
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
367
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

299
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
299

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancing screening, early diagnosis and treatment initiation of oral, breast and cervical cancer in selected districts of India: an implementation research protocol.

BMJ open·2026
Same author

Extracellular catalysis of environmental substrates by Shewanella oneidensis MR-1 occurs via active sites on the C-terminal domains of MtrC.

Protein science : a publication of the Protein Society·2025
Same author

Correlation of endoscopic findings, histopathological features and Helicobacter pylori infection in adult dyspeptic patients from the cold desert tribal region of Spiti Valley, Himachal Pradesh.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology·2025
Same author

Prevalence of hepatitis B and C virus infections among Buddhist tribes of Kaza health block, Lahaul and Spiti district of Himachal Pradesh.

The National medical journal of India·2025
Same author

Cyanophenylalanine as an Infrared Probe for Iron-Sulfur Cluster Redox State in Multicenter Metalloenzymes.

Chembiochem : a European journal of chemical biology·2025
Same author

A Study of Quality of Life of Elderly Live Kidney Donors-An Interview-Based Prospective Follow-Up Study.

Transplantation proceedings·2024

Related Experiment Video

Updated: Dec 27, 2025

An Electroporation Method to Transform Rickettsia spp. with a Fluorescent Protein-Expressing Shuttle Vector in Tick Cell Lines
07:18

An Electroporation Method to Transform Rickettsia spp. with a Fluorescent Protein-Expressing Shuttle Vector in Tick Cell Lines

Published on: October 11, 2022

2.3K

Rickettsioses in Children - A Review.

Ashwani K Sood1, Amit Sachdeva2

  • 1Department of Pediatrics and Adolescent Medicine, Indira Gandhi Medical College, Shimla, India. doc.aksood@gmail.com.

Indian Journal of Pediatrics
|March 1, 2020
PubMed
Summary

Scrub typhus, a severe rickettsial disease, is underdiagnosed in India. Early diagnosis and treatment of scrub typhus are crucial to prevent high mortality and organ dysfunction.

Keywords:
IgM ELISARickettiosisScrub typhus

More Related Videos

RNA Interference in Ticks
09:06

RNA Interference in Ticks

Published on: January 20, 2011

18.5K
Tick Artificial Membrane Feeding for Ixodes scapularis
08:53

Tick Artificial Membrane Feeding for Ixodes scapularis

Published on: November 30, 2022

4.1K

Related Experiment Videos

Last Updated: Dec 27, 2025

An Electroporation Method to Transform Rickettsia spp. with a Fluorescent Protein-Expressing Shuttle Vector in Tick Cell Lines
07:18

An Electroporation Method to Transform Rickettsia spp. with a Fluorescent Protein-Expressing Shuttle Vector in Tick Cell Lines

Published on: October 11, 2022

2.3K
RNA Interference in Ticks
09:06

RNA Interference in Ticks

Published on: January 20, 2011

18.5K
Tick Artificial Membrane Feeding for Ixodes scapularis
08:53

Tick Artificial Membrane Feeding for Ixodes scapularis

Published on: November 30, 2022

4.1K

Area of Science:

  • * Infectious Diseases
  • * Public Health
  • * Microbiology

Background:

  • * Rickettsial diseases, caused by Gram-negative bacteria, are emerging global health threats.
  • * Scrub typhus (ST), murine flea-borne typhus, and Indian tick typhus are frequently reported.
  • * Scrub typhus is a significant and underdiagnosed public health issue in India.

Purpose of the Study:

  • * To review the epidemiology, clinical manifestations, diagnostic methods, and treatment of scrub typhus.
  • * To highlight the challenges in diagnosing scrub typhus due to its variable and non-specific presentation.
  • * To emphasize the need for increased clinical suspicion and testing for scrub typhus.

Main Methods:

  • * Literature review of rickettsial diseases, with a focus on scrub typhus.
  • * Analysis of epidemiological trends, clinical presentations, and diagnostic challenges.
  • * Summary of current treatment guidelines and outcomes.

Main Results:

  • * Rickettsial infections, particularly scrub typhus, are often difficult to diagnose clinically.
  • * Delayed diagnosis and treatment of scrub typhus can lead to high fatality rates (30-45%) and multiple organ dysfunction.
  • * Scrub typhus is a vastly underdiagnosed entity in India, despite its public health significance.

Conclusions:

  • * Early clinical suspicion, prompt diagnosis, and timely antimicrobial therapy are essential for managing rickettsial diseases like scrub typhus.
  • * Increased awareness and diagnostic testing for scrub typhus among clinicians are necessary.
  • * Further research is needed to bridge the knowledge gap regarding rickettsioses and improve diagnostic accuracy.