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Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

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Published on: November 8, 2012

Test-retest reliability and long-term stability of three-tissue constrained spherical deconvolution methods for

Benjamin T Newman^1,2, Thijs Dhollander³, Kristen A Reynier⁴

¹Department of Radiology and Medical Imaging, School of Medicine, University of Virginia, Charlottesville, Virginia.

Magnetic Resonance in Medicine

|March 1, 2020

Summary

Quantitative metrics from diffusion-weighted MRI show reliable brain tissue microstructure composition up to 3 months. This stability supports using these metrics to track changes in brain pathologies.

Keywords:

MRI diffusion microstructure reliability spherical deconvolution

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Area of Science:

Neuroimaging
Biomedical Engineering
Quantitative MRI

Background:

Diffusion-weighted MRI (dMRI) enables quantitative assessment of brain tissue microstructure.
Three-tissue constrained spherical deconvolution (3T-CSD) models white matter, gray matter, and CSF-like compartments.
Reliability and longitudinal stability of 3T-CSD metrics are not well-established.

Purpose of the Study:

Evaluate the reliability and long-term stability of quantitative brain microstructure metrics derived from 3T-CSD.
Assess metrics across different test-retest intervals and acquisition parameters.
Determine the suitability of 3T-CSD for tracking microstructural changes in neurological conditions.

Main Methods:

Examined whole-brain microstructure estimates for white matter, gray matter, and CSF-like compartments.
Utilized three separate test-retest cohorts with varying intervals (immediate to 3 months).
Acquisition parameters differed across cohorts to ensure generalizability.

Main Results:

CSF-like compartment showed high reliability (ICC > 0.95) across all cohorts.
White and gray matter compartments demonstrated high reliability (ICC > 0.90) immediately but declined to ICC > 0.80 at 3 months.
Regional analysis of CSF-like signal in the hippocampus maintained high reliability (ICC > 0.80).

Conclusions:

3T-CSD provides reliable and stable quantitative estimates of brain tissue microstructure over 3 months in healthy individuals.
These findings support the use of 3T-CSD for longitudinal studies of brain pathologies.
Further research can leverage these stable metrics to investigate microstructural alterations in various neurological diseases.