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A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
Published on: September 16, 2017
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Iron Sucrose as MRI Contrast Agent in Ischemic Stroke Model
Shiman Wu1, Hua Zhang2, Jing Wang1
1Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Journal of Magnetic Resonance Imaging : JMRI
|March 1, 2020
Summary
Iron sucrose (IS) shows promise as an MRI contrast agent for MR angiography and perfusion imaging in stroke models. This study found IS comparable to gadolinium-based contrast agents in rats, suggesting its potential clinical utility.
Area of Science:
- Radiology
- Medical Imaging
- Neurology
Background:
- Growing safety concerns surround gadolinium-based contrast agents (GBCAs).
- Ferumoxytol, an alternative, has limitations for dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI).
Purpose of the Study:
- To evaluate iron sucrose (IS) as a contrast agent for MR angiography (MRA) and DSC-PWI.
- To assess IS feasibility in an ischemic stroke model.
Main Methods:
- Prospective animal study using rat models (n=72).
- MR angiography (MRA) and DSC-PWI performed at 3.0T.
- Comparison with arterial spin labeling (ASL) and GBCA-enhanced DSC-PWI.
Main Results:
- Iron sucrose (IS) demonstrated comparable signal-to-noise and contrast-to-noise ratios to GBCAs in MRA.
- IS-enhanced DSC-PWI effectively detected perfusion changes in middle cerebral artery occlusion (MCAO) rat models.
- Hyperperfusion was observed postreperfusion in MCAO rats using IS-mediated DSC-PWI.
Conclusions:
- Iron sucrose (IS) is a feasible and effective contrast agent for both MRA and DSC-PWI.
- IS presents a potential alternative to GBCAs in neuroimaging, particularly for stroke assessment.
