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Discovery, development, and future application of senolytics: theories and predictions
Erin O Wissler Gerdes1, Yi Zhu1, Tamar Tchkonia1
1Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
The FEBS Journal
|March 1, 2020
Summary
Senescent cells contribute to aging and disease. Senolytic drugs selectively eliminate these cells, offering a new approach to treat age-related conditions and diseases with promising early clinical trial results.
Area of Science:
- Gerontology
- Cellular Biology
- Pharmacology
Background:
- Senescent cells accumulate with aging and disease.
- These non-replicating cells can cause tissue dysfunction.
- Senescent cells remain viable despite their detrimental effects.
Purpose of the Study:
- To review the discovery of senolytic drugs.
- To discuss strategies for clinical translation of senolytics.
- To highlight early clinical trial findings for senolytic therapies.
Main Methods:
- Literature review of senolytic drug discovery.
- Analysis of senolytic drug development and clinical trial data.
- Synthesis of information on targeting cellular senescence.
Main Results:
- Senolytic drugs selectively eliminate senescent cells.
- Senolytics represent a novel therapeutic strategy for age-related diseases.
- Early clinical trials show promising signals for senolytic efficacy.
Conclusions:
- Senolytics target a fundamental aging mechanism.
- Targeting cellular senescence offers a protean approach to multiple disorders.
- Senolytics hold significant potential for alleviating age-related dysfunction and disease.
