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Organoids to study immune functions, immunological diseases and immunotherapy
Wenrui Ye1, Cong Luo2, Chenglong Li1
1Department of Neurosurgery, Xiangya Hospital, Central South University (CSU), Changsha, China; Clinical Medicine Eight-year Program, Xiangya Medical School of Central South University, Changsha, Hunan, China.
Cancer Letters
|March 1, 2020
Summary
Organoids are revolutionizing immunology research by providing advanced 3D models that mimic the body. These models enhance the study of immune diseases and cancer, paving the way for personalized immunotherapy.
Area of Science:
- Immunology
- Biotechnology
- Cell Biology
Background:
- Three-dimensional organoid culture systems offer advanced physiological and pathophysiological models.
- Organoids closely mimic the in vivo microenvironment, enabling in-depth understanding of immune tissue structures and functions.
- Recent advancements include coculture organoid and air-liquid interface (ALI) systems for studying epithelia-immune cell interactions.
Purpose of the Study:
- To provide an overview of recent advances in applying organoids to immunological research.
- To discuss the potential of organoids in developing innovative immunological disease models.
- To explore the link between immunity and cancer, highlighting potential for personalized immunotherapy.
Main Methods:
- Review of current literature on organoid applications in immunology.
- Analysis of novel organoid systems like coculture and ALI for studying cell interactions.
- Examination of organoid utility in modeling immune-related diseases and cancer.
Main Results:
- Organoids facilitate functional studies of immune system conditions in a near-native context.
- Coculture and ALI organoid systems offer new insights into epithelia-immune cell interactions.
- Organoids are instrumental in creating novel immunological disease models and exploring cancer-immunity links.
Conclusions:
- Organoid technology is a powerful tool for advancing immunological research and understanding complex biological systems.
- Organoids show significant potential for the development of personalized immunotherapy strategies.
- Further improvements in organoid systems can unlock greater potential for clinical applications in immunotherapy.
