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Predict or draw blood: An integrated method to reduce lab tests.

Lishan Yu1, Qiuchen Zhang2, Elmer V Bernstam3

  • 1School of Biomedical Informatics, UTHealth, United States; Department of Mathematical Sciences, Tsinghua University, China.

Journal of Biomedical Informatics
|March 1, 2020
PubMed
Summary
This summary is machine-generated.

This study introduces a deep learning method to reduce expensive and potentially harmful serial laboratory testing. The model successfully omitted 15% of tests with minimal accuracy loss, optimizing clinical decision-making.

Keywords:
Clinical informaticsCombinatorial optimizationLaboratory test reductionRecurrent neural networkTime series data

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Area of Science:

  • Artificial Intelligence
  • Clinical Informatics
  • Healthcare Management

Background:

  • Serial laboratory testing is a standard but costly practice in healthcare, particularly in Intensive Care Units (ICUs).
  • Repeated lab tests incur significant expenses and pose potential risks to patient well-being.
  • Identifying which specific lab tests can be safely omitted presents a complex optimization challenge due to the vast number of tests and decision trajectories.

Purpose of the Study:

  • To develop a novel deep-learning framework for predicting and omitting unnecessary serial laboratory tests.
  • To jointly forecast future lab test events for omission and estimate their values based on observed data.
  • To address the challenge of optimizing test reduction in a time-dependent decision-making context.

Main Methods:

  • Proposed a novel, concise deep-learning architecture for joint prediction of lab test omission and omitted event values.
  • Utilized observed testing values to train the model on time-series data.
  • Focused on modeling the temporal dynamics of clinical laboratory testing decisions.

Main Results:

  • Achieved a 15% reduction in the number of serial laboratory tests performed.
  • Maintained a prediction accuracy loss of less than 5% despite test omission.
  • Demonstrated the efficacy of the deep-learning approach in optimizing lab test utilization.

Conclusions:

  • The developed deep-learning method effectively reduces the frequency of serial laboratory testing without significant loss of predictive accuracy.
  • The framework offers a generalizable solution for optimizing decision-making in similar business and clinical contexts involving sequential data.
  • This approach has the potential to decrease healthcare costs and mitigate patient risks associated with excessive testing.