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Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

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Updated: Dec 27, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Cardiac resynchronization therapy modulates peripheral sympathetic activity.

Pei-Lin Xiao1, Cheng Cai2, Pei Zhang3

  • 1Department of Cardiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Heart Rhythm
|March 2, 2020
PubMed
Summary
This summary is machine-generated.

Cardiac resynchronization therapy (CRT) reduces sympathetic nerve activity in heart failure with reduced ejection fraction (HFrEF) patients. This reduction is linked to improved heart function, particularly in CRT responders.

Keywords:
Cardiac resynchronization therapyHeart failureHeart rate variabilitySkin sympathetic nerve activitySympathetic nerve system

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Area of Science:

  • Cardiology
  • Neuroscience
  • Biomedical Engineering

Background:

  • Heightened sympathetic nerve activity is linked to poor prognosis in heart failure with reduced ejection fraction (HFrEF).
  • Understanding interventions that modulate sympathetic activity is crucial for improving HFrEF outcomes.

Purpose of the Study:

  • To investigate the impact of cardiac resynchronization therapy (CRT) on sympathetic nerve activity.
  • To assess changes in average skin sympathetic nerve activity (aSKNA) following CRT.

Main Methods:

  • A prospective study involving 36 HFrEF patients receiving CRT and 10 control patients.
  • Collected clinical data, echocardiographic variables, and aSKNA at baseline and 3-month follow-up.
  • Compared aSKNA based on QRS duration and CRT response.

Main Results:

  • CRT patients with wider QRS duration had higher baseline aSKNA compared to controls.
  • Following CRT, left ventricular ejection fraction (LVEF) improved significantly.
  • aSKNA decreased significantly post-CRT, especially in CRT responders with LVEF improvement.
  • Reduced aSKNA correlated with improved LVEF.

Conclusions:

  • Cardiac resynchronization therapy effectively reduces sympathetic overactivity in HFrEF patients.
  • The reduction in sympathetic activity is associated with short-term improvements in systolic function.
  • CRT responders demonstrate a more pronounced decrease in sympathetic activity.