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Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia
Diana Petroi1, Joseph R Duffy1, Andrew Borgert2
1Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Brain and Language
|March 2, 2020
Summary
Neuroimaging reveals that atrophy in the inferior parietal lobe and supramarginal gyrus is linked to phonologic errors in logopenic variant primary progressive aphasia (lvPPA). This finding highlights key brain regions associated with speech sound errors in lvPPA.
Area of Science:
- Neuroimaging
- Neurology
- Speech and Language Pathology
Background:
- Phonologic errors are a key feature of logopenic variant primary progressive aphasia (lvPPA).
- Limited neuroimaging data exist on the brain regions associated with these errors in lvPPA.
Purpose of the Study:
- To identify specific left hemisphere gray matter regions correlated with phonologic errors in individuals with lvPPA.
- To investigate the relationship between different types of phonologic errors and brain atrophy patterns.
Main Methods:
- Correlational analyses were performed on data from 20 participants with lvPPA.
- Phonologic errors across tasks designed to elicit them were analyzed.
- Gray matter volumes in specific left hemisphere regions were measured.
Main Results:
- The inferior parietal lobe and supramarginal gyrus showed significant correlations with phonologic errors.
- Atrophy in these parietal regions was associated with an increased likelihood of phonologic errors, especially substitution types.
Conclusions:
- The findings support the inferior parietal lobe and supramarginal gyrus as critical neuroanatomical correlates of phonologic errors in lvPPA.
- Parietal region atrophy may underlie the phonologic deficits observed in lvPPA, aligning with prior research on temporoparietal involvement.
Keywords:
Logopenic progressive aphasiaNeuroanatomical correlatesNeuroimagingPhonologic errorsPrimary progressive aphasiaMore Related Videos
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