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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
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Related Experiment Video

Updated: Dec 27, 2025

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
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Quantitative imaging for radiotherapy purposes.

Oliver J Gurney-Champion1, Faisal Mahmood2, Marcel van Schie3

  • 1Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
|March 2, 2020
PubMed
Summary
This summary is machine-generated.

Quantitative imaging biomarkers enhance radiotherapy by improving target accuracy and predicting treatment response. This review discusses standards for CT, PET, and MRI, identifying critical issues and future research in radiation oncology.

Keywords:
BiomarkersMultimodal imagingMultiparametric magnetic resonance imagingPositron-emission tomographyRadiotherapyReviewTumor

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Area of Science:

  • Radiotherapy
  • Medical Imaging
  • Biomarkers

Background:

  • Quantitative imaging biomarkers offer potential in radiotherapy.
  • They can improve radiotherapy target delineation.
  • Biomarkers may predict treatment response and aid stratification.

Purpose of the Study:

  • To review standards, guidelines, and recommendations for quantitative imaging assessment.
  • To identify critical issues and future research directions for quantitative imaging in radiation oncology.

Main Methods:

  • Review of published standards, guidelines, and recommendations.
  • Discussion of quantitative imaging assessment using CT, PET, and MRI.

Main Results:

  • Quantitative imaging can improve radiotherapy target contouring.
  • It can predict treatment response and stratify patients.
  • It enables personalized radiation doses, including dose painting.

Conclusions:

  • Quantitative imaging holds significant promise for advancing radiotherapy.
  • Further research is needed to address critical issues in its application.
  • Established standards are crucial for reliable implementation.